Persistent unconjugated hyperbilirubinemia after liver transplantation due to an abnormal bilirubin UDP-glucuronosyltransferase gene promotor sequence in the donor
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UvA - DARE ( Digital Academic Repository ) Persistent unconjugated hyperbilirubinemia after liver transplantation due to an abnormal bilirubin UDP - glucuronosyltransferase gene promotor sequence in the donor
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متن کاملProlonged unconjugated hyperbilirubinemia associated with breast milk and mutations of the bilirubin uridine diphosphate- glucuronosyltransferase gene.
OBJECTIVE Breast milk jaundice is a common problem in nursing infants. It has been ascribed to various breast milk substances, but the component or combination of components that is responsible remains unknown. During our study of defects of the bilirubin uridine diphosphate-glucuronosyltransferase gene (UGT1A1) in patients with hereditary unconjugated hyperbilirubinemia (Crigler-Najjar syndrom...
متن کاملSerum Bilirubin Affects Graft Outcomes through UDP-Glucuronosyltransferase Sequence Variation in Kidney Transplantation
BACKGROUND Oxidative stress is a major mediator of adverse outcome after kidney transplantation. Bilirubin is produced by heme oxygenase-1 (HO-1), catalyzed by UDP-glucuronosyltransferase (UGT1A1), and has potential as an antioxidant. In this study, we investigated the effects of HO-1 and UGT1A1 sequence variations on kidney allograft outcomes. METHODS Clinical data were collected from 429 Ko...
متن کاملGly71Arg mutation of the bilirubin UDP-glucuronosyltransferase 1A1 gene is associated with neonatal hyperbilirubinemia in the Japanese population.
The serum bilirubin level of Japanese newborn infants in their first few days is significantly higher than that in Caucasian newborn infants, suggesting that there might be genetic risk factors for the development of neonatal hyperbilirubinemia in the Japanese population. Recently, it has been reported that a variant TATA box in the promoter region of the bilirubin UDP-glucuronosyltransferase 1...
متن کاملUnconjugated hyperbilirubinemia in a blood donor: Chance finding due to unusual plasma discoloration
We received a blood donation from a 29‐year‐old repeat voluntary male donor, donating first time at our center. He gave a history of jaundice 3 years back with no known cause of jaundice but presently healthy. His hemoglobin was 17.1 by Hemocue 301 analyzer. Since he met the criteria for blood donation,[1‐3] we accepted the donor. At our center, visual inspection of components is a routine prot...
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ژورنال
عنوان ژورنال: Journal of Hepatology
سال: 1997
ISSN: 0168-8278
DOI: 10.1016/s0168-8278(97)80272-3